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In project A11 we will apply sequence-controlled oligo(amidoamines) as a new platform for the multivalent presentation of non-natural supramolecular binding motifs such as the molecular tweezer from the Schrader group or guanidiniocarbonylpyrrole cations from the Schmuck group in combination with biological ligands as well as sensor molecules e.g. from the Voskuhl group. The resulting macromolecular ligands will be analyzed for their modulation of different proteins under investigation within the CRC and we will try to derive new insights into the design and applications of supramolecular ligands based on multivalent macromolecules.
Figure: Exemplary structures of oligo(amidoamines) carrying tweezer groups and their potential interactions with different protein targets depending on the sequence and position of the supramolecular binding motif within the macromolecular ligand
Jacobi, F.; Wilms, D.; Seiler, T.; Queckbörner, T.; Tabatabai, M.; Hartmann, L.; Schmidt, S., “The effect of PEGylation on receptor anchoring and steric shielding at interfaces: an adhesion and surface plasmon resonance study with precision polymers”. Biomacromolecules. 2020, Just-Accepted Manuscript. Pub Date: September 28, 2020. Link
van der Meer, S. B.; Seiler, T.; Buchmann, C.; Partalidou, G.; Boden, S.; Loza, K.; Heggen, M.; Linders, J.; Prymak, O., Hartmann, L.; Oliveira, C. L. P.; Epple, M., “Controlling the surface functionalization of ultrasmall gold nanoparticles by sequence-defined macromolecules.“ Chemistry – A European Journal. 2020, 26, 202003804. Link